R Functions for Chapter 3,4,6,7,9,10,11,12,14,15 of Sample Size
Calculation in Clinical Research
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Documentation for package ‘TrialSize’ version 1.4
Help Pages
| TrialSize-package | Sample Size calculation in Clinical Research |
| AB.withDescalation | A + B Escalation Design with Dose De-escalation |
| AB.withoutDescalation | A + B Escalation Design without Dose De-escalation |
| ABE | Average Bioequivalence |
| ANOVA.Repeat.Measure | ANOVA with Repeat Measures |
| Carry.Over | Test the Carry-over effect |
| Cochran.Armitage.Trend | Cochran-Armitage's Test for Trend |
| Cox.Equality | Test for equality in Cox PH model. |
| Cox.Equivalence | Test for Equivalence in Cox PH model. |
| Cox.NIS | Test for non-inferiority/superiority in Cox PH model. |
| CrossOver.ISV.Equality | Test for Equality of Intra-Subject Variabilities in Crossover Design |
| CrossOver.ISV.Equivalence | Test for Similarity of Intra-Subject Variabilities in Crossover Design |
| CrossOver.ISV.NIS | Test for Non-Inferiority/Superiority of Intra-Subject Variabilitie in Crossover Design |
| Dose.Min.Effect | Williams' Test for Minimum effective dose (MED) |
| Dose.Response.binary | Linear Contrast Test for Binary Dose Response Study |
| Dose.Response.Linear | Linear Contrast Test for Dose Response Study |
| Dose.Response.time.to.event | Linear Contrast Test for Time-to-Event Endpoint in dose response study |
| gof.Pearson | Test Goodness of Fit by Pearson's Test |
| gof.Pearson.twoway | Test Goodness of Fit by Pearson's Test for two-way table |
| IBE | Individual Bioequivalence |
| InterSV.Equality | Test for Equality of Inter-Subject Variabilities |
| InterSV.NIS | Test for Equality of Inter-Subject Variabilities |
| ISCV.Equality | Test for Equality of Intra-Subject CVs |
| ISCV.Equivalence | Test for Equivalence of Intra-Subject CVs |
| ISCV.NIS | Test for Non-Inferiority/Superiority of Intra-Subject CVs |
| ISV.Equality | Test for Equality of Intra-Subject Variabilities |
| ISV.Equivalence | Test for Similarity of Intra-Subject Variabilities |
| ISV.NIS | Test for Non-Inferiority/Superiority of Intra-Subject Variabilities |
| McNemar.Test | McNemar Test in 2 by 2 table |
| MeanWilliamsDesign.Equality | Test for Equality in Multiple-Sample William Design |
| MeanWilliamsDesign.Equivalence | Test for Equivalence in Multiple-Sample William Design |
| MeanWilliamsDesign.NIS | Test for Non-Inferiority/Superiority in Multiple-Sample William Design |
| Multiple.Testing | Multiple Testing procedures |
| Nonpara.Independ | Test for independence for nonparametric study |
| Nonpara.One.Sample | One Sample Location problem in Nonparametric |
| Nonpara.Two.Sample | Two sample location problem for Nonparametric |
| OneSampleMean.Equality | One Sample Mean Test for Equality |
| OneSampleMean.Equivalence | One Sample Mean Test for Equivalence |
| OneSampleMean.NIS | One Sample Mean Test for Non-Inferiority/Superiority |
| OneSampleProportion.Equality | One sample proportion test for equality |
| OneSampleProportion.Equivalence | One sample proportion test for equivalence |
| OneSampleProportion.NIS | One sample proportion test for Non-inferiority/Superiority |
| OneSide.fixEffect | One-Sided Tests with fixed effect sizes |
| OneSide.varyEffect | One-Sided Tests with varying effect sizes |
| OneWayANOVA.pairwise | Pairwise Comparison for Multiple-Sample One-Way ANOVA |
| OneWayANOVA.PairwiseComparison | One-way ANOVA pairwise comparison |
| PBE | Population Bioequivalence |
| Propensity.Score.nostrata | Propensity Score ignoring strata |
| Propensity.Score.strata | Propensity Score with Stratas |
| QOL | Quality of life |
| QT.crossover | Crossover Design in QT/QTc Studies without covariates |
| QT.parallel | Parallel Group Design in QT/QTc Studies without covariates |
| QT.PK.crossover | Crossover Design in QT/QTc Studies with PK response as covariate |
| QT.PK.parallel | Parallel Group Design in QT/QTc Studies with PK response as covariate |
| RelativeRisk.Equality | Relative Risk in Parallel Design test for Equality |
| RelativeRisk.Equivalence | Relative Risk in Parallel Design test for Equivalence |
| RelativeRisk.NIS | Relative Risk in Parallel Design test for Non-inferiority/Superiority |
| RelativeRiskCrossOver.Equality | Relative Risk in Crossover Design test for Equality |
| RelativeRiskCrossOver.Equivalence | Relative Risk in Crossover Design test for Equivalence |
| RelativeRiskCrossOver.NIS | Relative Risk in Crossover Design test for Non-inferiority/Superiority |
| Sensitivity.Index | Calculate the power for Sensitivity Index |
| Stuart.Maxwell.Test | Stuart-Maxwell Test |
| TrialSize | Sample Size calculation in Clinical Research |
| TwoSampleCrossOver.Equality | Two Sample Crossover Design Test for Equality |
| TwoSampleCrossOver.Equivalence | Two Sample Crossover Design Test for Equivalence |
| TwoSampleCrossOver.NIS | Two Sample Crossover Design Test for Non-Inferiority/Superiority |
| TwoSampleMean.Equality | Two Sample Mean Test for Equality |
| TwoSampleMean.Equivalence | Two Sample Mean Test for Equivalence |
| TwoSampleMean.NIS | Two Sample Mean Test for Non-Inferiority/Superiority |
| TwoSampleProportion.Equality | Two sample proportion test for equality |
| TwoSampleProportion.Equivalence | Two sample proportion test for equivalence |
| TwoSampleProportion.NIS | Two sample proportion test for Non-Inferiority/Superiority |
| TwoSampleSeqCrossOver.Equality | Two sample proportion Crossover design test for equality |
| TwoSampleSeqCrossOver.Equivalence | Two sample proportion Crossover design test for equivalence |
| TwoSampleSeqCrossOver.NIS | Two sample proportion Crossover design for Non-inferiority/Superiority |
| TwoSampleSurvival.Conditional | Test for two sample conditional data in exponential model for survival data |
| TwoSampleSurvival.Equality | Test for two sample equality in exponential model for survival data |
| TwoSampleSurvival.Equivalence | Test for two sample equivalence in exponential model for survival data |
| TwoSampleSurvival.NIS | Test for two sample Non-Inferiority/Superiority in exponential model for survival data |
| TwoSide.fixEffect | Two-Sided Tests with fixed effect sizes |
| TwoSide.varyEffect | Two-Sided Tests with varying effect sizes |
| Vaccine.CEM | Composite Efficacy Measure(CEM) for Vaccine clinical trials. |
| Vaccine.ELDI | The evaluation of vaccine efficacy with Extremely Low Disease Incidence(ELDI) |
| Vaccine.RDI | Reduction in Disease Incidence(RDI) for Vaccine clinical trials. |
| Vitro.BE | In Vitro Bioequivalence |
| WilliamsDesign.Equality | William Design test for equality |
| WilliamsDesign.Equivalence | Williams Design test for equivalence |
| WilliamsDesign.NIS | Williams Design test for Non-inferiority/Superiority |