ANOVA.Repeat.Measure {TrialSize}

ANOVA with Repeat Measures

Description

The study has multiple assessments in a parallel-group clinical trial. \alpha_i is the fixed effect for the ith treatment \sum \alpha_i =0.

Ho: \alpha_{i} = \alpha_{i'}

Ha: not equal

Usage

ANOVA.Repeat.Measure(alpha, beta, sigma, delta, m)

Arguments

alpha

significance level

beta

power = 1-beta

sigma

sigma^2 is the sum of the variance components.

delta

a clinically meaningful difference

m

Bonferroni adjustment for alpha, totally m pairs comparison.

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

Example.15.3.4<-ANOVA.Repeat.Measure(0.05,0.2,1.25,1.5,3)
Example.15.3.4
# 15