RelativeRiskCrossOver.NIS {TrialSize}

Relative Risk in Crossover Design test for Non-inferiority/Superiority

Description

Ho: log(OR) \le margin

Ha: log(OR) > margin

Usage

RelativeRiskCrossOver.NIS(alpha, beta, sigma, or, margin)

Arguments

alpha

significance level

beta

power = 1-beta

sigma

standard deviation in crossover design

or

or=pt(1-pc)/pc(1-pt)

margin

the superiority or non-inferiority margin

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003