TwoSampleProportion.Equivalence {TrialSize}

Two sample proportion test for equivalence

Description

Ho: |p1-p2| \ge margin

Ha: |p1-p2| < margin

The proportion of response p1 is equivalent to the reference drug p2 is the null hypothesis is rejected

Usage

TwoSampleProportion.Equivalence(alpha, beta, p1, p2, k, delta, margin)

Arguments

alpha

significance level

beta

power = 1-beta

p1

the mean response rate for test drug

p2

the rate for reference drug

k

k=n1/n2

delta

delta=p1-p2

margin

the superiority or non-inferiority margin

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

Example.4.2.4<-TwoSampleProportion.Equivalence(0.05,0.2,0.75,0.8,1,0.2,0.05)
Example.4.2.4