WilliamsDesign.NIS {TrialSize}

Williams Design test for Non-inferiority/Superiority

Description

H0: \mu_1-\mu_2 \le margin

Ha: \mu_1-\mu_2 > margin

Usage

WilliamsDesign.NIS(alpha, beta, sigma, sequence, delta, margin)

Arguments

alpha

significance level

beta

power = 1-beta

sigma

standard deviation in crossover design

sequence

total sequence number

delta

the superiority or non-inferiority margin

margin

margin=\mu_1-\mu_2

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

Example.4.5.4<-WilliamsDesign.NIS(0.05,0.2,0.75^2,6,0.2,0.05)
Example.4.5.4