TwoSampleSurvival.Equality {TrialSize}

Test for two sample equality in exponential model for survival data

Description

H0: the difference between the hazard rates of two samples is equal to

Ha: not equal to 0

The test is finding whether there is a difference between the hazard rates of the test drug and the reference drug.

Usage

TwoSampleSurvival.Equality(alpha, beta, lam1, lam2, k, ttotal, taccrual, gamma)

Arguments

alpha

significance level

beta

power = 1-beta

lam1

the hazard rates of control group

lam2

the hazard rates of a test drug

k

k=n1/n2 sample size ratio

ttotal

Total trial time

taccrual

accrual time period

gamma

parameter for exponential distribution. Assume Uniform patient entry if gamma =0

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

Example.7.2.4<-TwoSampleSurvival.Equality(0.05,0.2,1,2,1,3,1,0.00001)
Example.7.2.4