Dose.Response.binary {TrialSize}

Linear Contrast Test for Binary Dose Response Study

Description

pi is the proportion of response in the ith group.

Ho: p1=p2=...=pk

Ha: L(p)= \sum ci \times pi = \epsilon, not equal to 0

Usage

Dose.Response.binary(alpha, beta, pi, ci, fi)

Arguments

alpha

significance level

beta

power = 1-beta

pi

pi is the proportion of response in the ith group.

ci

a linear contrast coefficients ci with \sum ci=0 .

fi

fi=ni/n is the sample size fraction for the ith group

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

pi=c(0.05,0.12,0.14,0.16);
ci=c(-6,1,2,3);

Example.11.2<-Dose.Response.binary(alpha=0.05,beta=0.2,pi=pi,ci=ci,fi=1/4)
Example.11.2
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