Vaccine.RDI {TrialSize}

Reduction in Disease Incidence(RDI) for Vaccine clinical trials.

Description

The test is to find whether the vaccine can prevent the disease or reduce the incidence of the disease in the target population. Usually use prospective, randomized, placebo-controlled trials.

Usage

Vaccine.RDI(alpha, d, pt, pc)

Arguments

alpha

significance level

d

the half length of the confidence interval of pt/pc

pt

the true disease incidence rates of the nt vaccines

pc

the true disease incidence rates of the nc controls

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

Example.15.6.1<-Vaccine.RDI(0.05,0.2,0.01,0.02)
Example.15.6.1
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