ISV.Equivalence {TrialSize}

Test for Similarity of Intra-Subject Variabilities

Description

the ratio = within-subject variance of treatment T / within-subject variance of treatment R

Ho: the ratio \ge \delta or the ratio \le \frac{1}{\delta}

Ha: \le \frac{1}{\delta} < the ratio < \delta

Usage

ISV.Equivalence(alpha, beta, sigma1, sigma2, m, margin)

Arguments

alpha

significance level

beta

power = 1-beta

sigma1

within-subject variance of treatment 1

sigma2

within-subject variance of treatment 2

m

for each subject, there are m replicates.

margin

margin=delta, the true ratio of sigma1/sigma2

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003