AB.withoutDescalation {TrialSize} | R Documentation |
A + B Escalation Design without Dose De-escalation
Description
The general A+B designs without dose de-escalation. There are A patients at dose level i.
(1) If less than C/A patients have dose limiting toxicity (DLTs), then the dose is escalated to the next dose level i+1.
(2)If more than D/A (D \ge
C) patients have DLTs, then the previous dose i-1 will be considered the maximum tolerable dose (MTD).
(3)If no less than C/A but no more than D/A patients have DLTs, B more patients are treated at this dose level i.
(4)If no more than E (where E \ge
D) of the total A+B patients have DLT, then the dose is escalated.
(5)If more than E of the total of A+B patients have DLT, then the previous dose i-1 will be considered the MTD.
Usage
AB.withoutDescalation(A, B, C, D, E, DLT)
Arguments
A |
number of patients for the start A |
B |
number of patients for the continuous B |
C |
number of patients for the first cut off C |
D |
number of patients for the second cut off D, D |
E |
number of patients for the third cut off D, E |
DLT |
dose limiting toxicity rate for each dose level. |
References
Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003
Examples
DLT=c(0.01,0.014,0.025,0.056,0.177,0.594,0.963)
Example.11.6.1<-AB.withoutDescalation(A=3,B=3,C=1,D=1,E=1,DLT=DLT)
Example.11.6.1
# Example.11.6.1[1]=3.1