Clinical Pharmacokinetics Toolkit


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Documentation for package ‘clinPK’ version 0.9.0

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clinPK-package clinPK
add_ruv Add residual variability to data
as.num factors or characters to numeric
auc2dose Convert AUCtau or AUCt to dose (for 1-compartment linear PK model)
calc_abw Calculate adjusted body weight (ABW)
calc_amts_for_conc Calculate the amounts in all compartments in a compartmental PK system based on a given concentration in the central compartment, and assuming steady state.
calc_bmi Calculate BMI
calc_bsa Calculate body surface area
calc_creat Estimate serum creatinine
calc_creat_neo Estimate serum creatinine in neonates
calc_egfr Calculate eGFR
calc_egfr_cystatin Calculate eGFR based on Cystatin C measurements
calc_ffm Calculate fat-free mass
calc_ibw Calculate ideal body weight for children and adults
calc_kel_single_tdm Calculate elimination rate when given a single TDM sample
calc_lbw Calculate lean body weight
calc_t12 Calculate half-life based on two points
cm2inch Convert cm to inch
conc2mol Convert concentration to molar
convert_creat_assay Convert serum creatinine from various assays to Jaffe
convert_creat_unit Convert creatinine to different unit
dose2auc Convert dose to expected AUCinf or AUCt for 1 compartment linear PK model
find_nearest_dose Generic function to calculate the dose nearest to a specific dose unit increment
find_nearest_interval Generic function to calculate the interval nearest to a possible dosing interval
inch2cm Convert inch to cm
is.nil Check if values in vector are empty
kg2lbs Convert kg to lbs
lbs2kg Convert lbs to kg
mol2conc Convert molar to concentration
nca Perform an NCA based on a NONMEM-style dataset
pct_bmi_for_age Percentile BMI for age for children
pct_for_age_generic Percentile height or weight for age for children
pct_height_for_age Percentile height for age for children
pct_weight_for_age Percentile weight for age for children
pk_1cmt_bolus Concentration predictions for 1-compartmental PK model after single or multiple bolus doses
pk_1cmt_bolus_cmax_ss Cmax for linear 1-compartment PK model at steady state, bolus dosing
pk_1cmt_bolus_cmin_ss Cmin (trough) for linear 1-compartment PK model at steady state, bolus dosing
pk_1cmt_bolus_dose_from_cmax Calculate dose to achieve steady state Cmax for 1-compartmental PK model bolus dosing at steady state
pk_1cmt_bolus_dose_from_cmin Calculate dose to achieve steady state trough for 1-compartmental PK model bolus dosing at steady state
pk_1cmt_bolus_ss Concentration predictions for 1-compartmental PK model with bolus dosing at steady state
pk_1cmt_inf Concentration predictions for 1-compartmental PK model after single or multiple bolus doses
pk_1cmt_inf_cmax_ss Cmax for linear 1-compartment PK model at steady state
pk_1cmt_inf_cmin_ss Cmin (trough) for linear 1-compartment PK model at steady state
pk_1cmt_inf_dose_from_cmax Calculate dose to achieve steady state Cmax for 1-compartmental PK model with infusion dosing at steady state
pk_1cmt_inf_dose_from_cmin Calculate dose to achieve steady state trough for 1-compartmental PK model with infusion dosing at steady state
pk_1cmt_inf_ss Concentration predictions for 2-compartmental PK model with infusion dosing at steady state
pk_1cmt_oral Concentration predictions for 1-compartmental oral PK model after single or multiple bolus doses
pk_1cmt_t12 Calculate terminal half-life for 1-compartment model
pk_2cmt_bolus Concentration predictions for 1-compartmental PK model, single or multiple bolus doses
pk_2cmt_bolus_cmax_ss Cmax for 2-compartmental PK model, bolus dosing at steady state
pk_2cmt_bolus_cmin_ss Cmin (trough) for 2-compartmental PK model, bolus dosing at steady state
pk_2cmt_bolus_dose_from_cmax Calculate dose to achieve steady state Cmax for 2-compartmental PK model bolus dosing at steady state
pk_2cmt_bolus_dose_from_cmin Calculate dose to achieve steady state trough for 2-compartmental PK model bolus dosing at steady state
pk_2cmt_bolus_ss Concentration predictions for 2-compartmental PK model, bolus dosing at steady state
pk_2cmt_inf Concentration predictions for 1-compartmental PK model, single or multiple infusions
pk_2cmt_inf_cmax_ss Cmax (trough) for 2-compartmental PK model, bolus dosing at steady state
pk_2cmt_inf_cmin_ss Cmin (trough) for 2-compartmental PK model, bolus dosing at steady state
pk_2cmt_inf_dose_from_cmax Calculate dose to achieve steady state Cmax for 2-compartmental PK model with infusion dosing at steady state
pk_2cmt_inf_dose_from_cmin Calculate dose to achieve steady state trough for 2-compartmental PK model with infusion dosing at steady state
pk_2cmt_inf_ss Concentration predictions for 1-compartmental PK model with infusion dosing at steady state
pk_2cmt_t12 Calculate half-life(s) for 2-compartment model
pk_2cmt_t12_interval Calculate average half-life for 2-compartment model during a specific interval
read_who_table Internal function to read WHO growth tables from package or download from WHO
weight2kg Convert any weight unit to kg