Clinical Pharmacokinetics Toolkit

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Documentation for package ‘clinPK’ version 0.13.0

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absolute2relative_bsa Convert quantity expressed in absolute units relative to normalized BSA
accumulation_ratio Calculate accumulation ratio This is the ratio of drug concentration or AUC at steady state over concentrations after single dose
add_ruv Add residual variability to data
auc2dose Convert AUCtau or AUCt to dose (for 1-compartment linear PK model)
calc_abw Calculate adjusted body weight (ABW)
calc_aki_stage Calculate AKI stage
calc_amts_for_conc Calculate the amounts in all compartments in a compartmental PK system based on a given concentration in the central compartment, and assuming steady state.
calc_baseline_scr Calculate baseline sCr
calc_bmi Calculate BMI
calc_bsa Calculate body surface area
calc_carboplatin_calvert Calvert equation for carboplatin
calc_creat Estimate serum creatinine
calc_creat_neo Estimate serum creatinine in neonates
calc_dosing_weight Calculate commonly used "dosing weight"
calc_egfr Calculate eGFR
calc_egfr_cystatin Calculate eGFR based on Cystatin C measurements
calc_ffm Calculate fat-free mass
calc_ibw Calculate ideal body weight in kg for children and adults
calc_kel_double_tdm Calculate elimination rate when given two TDM samples
calc_kel_single_tdm Calculate elimination rate when given a single TDM sample
calc_kgfr Calculate kinetic GFR
calc_lbw Calculate lean body weight
calc_neutropenia_grade Calculate neutropenia grade from ANC
calc_t12 Calculate half-life based on two points
check_covs_available Checks whether required covariates for eGFR calculations are present
cm2inch Convert cm to inch
conc2mol Convert concentration to molar
convert_albumin_unit Convert albumin from / to units
convert_bilirubin_unit Convert bilirubin from / to units
convert_creat_assay Convert serum creatinine from various assays to Jaffe
convert_creat_unit Convert creatinine to different unit
convert_flow_unit Convert flow (e.g. clearance) from / to units
dose2auc Convert dose to expected AUCinf or AUCt for 1 compartment linear PK model
egfr_cov_reqs Returns parameters needed to calculate eGFR according to the method specified.
find_nearest_dose Generic function to calculate the dose nearest to a specific dose unit increment
find_nearest_interval Generic function to calculate the interval nearest to a possible dosing interval
fraction_of_ss Calculate fraction of steady state at particular time after start of dosing
ibw_devine Calculate ideal body weight in kg for children and adults
ibw_standard Calculate ideal body weight in kg for children and adults
inch2cm Convert inch to cm
kg2lbs Convert kg to lbs
kg2oz Convert kg to oz
lbs2kg Convert lbs to kg
mol2conc Convert molar to concentration
nca Perform an NCA based on a NONMEM-style dataset
oz2kg Convert oz to kg
pct_bmi_for_age Percentile BMI for age for children
pct_height_for_age Percentile height for age for children
pct_weight_for_age Percentile weight for age for children
pk_1cmt_bolus Concentration predictions for 1-compartmental PK model after single or multiple bolus doses
pk_1cmt_bolus_cmax_ss Cmax for linear 1-compartment PK model at steady state, bolus dosing
pk_1cmt_bolus_cmin_ss Cmin (trough) for linear 1-compartment PK model at steady state, bolus dosing
pk_1cmt_bolus_dose_from_cmax Calculate dose to achieve steady state Cmax for 1-compartmental PK model bolus dosing at steady state
pk_1cmt_bolus_dose_from_cmin Calculate dose to achieve steady state trough for 1-compartmental PK model bolus dosing at steady state
pk_1cmt_bolus_ss Concentration predictions for 1-compartmental PK model with bolus dosing at steady state
pk_1cmt_inf Concentration predictions for 1-compartmental PK model after single or multiple bolus doses
pk_1cmt_inf_cmax_ss Cmax for linear 1-compartment PK model at steady state
pk_1cmt_inf_cmin_ss Cmin (trough) for linear 1-compartment PK model at steady state
pk_1cmt_inf_dose_for_range Calculate dose based on a given AUC24, Cmax, and Cmin, assuming 1-compartment model
pk_1cmt_inf_dose_from_cmax Calculate dose to achieve steady state Cmax for 1-compartmental PK model with infusion dosing at steady state
pk_1cmt_inf_dose_from_cmin Calculate dose to achieve steady state trough for 1-compartmental PK model with infusion dosing at steady state
pk_1cmt_inf_ss Concentration predictions for 2-compartmental PK model with infusion dosing at steady state
pk_1cmt_oral Concentration predictions for 1-compartmental oral PK model after single or multiple bolus doses
pk_1cmt_t12 Calculate terminal half-life for 1-compartment model
pk_2cmt_bolus Concentration predictions for 2-compartmental PK model, single or multiple bolus doses
pk_2cmt_bolus_cmax_ss Cmax for 2-compartmental PK model, bolus dosing at steady state
pk_2cmt_bolus_cmin_ss Cmin (trough) for 2-compartmental PK model, bolus dosing at steady state
pk_2cmt_bolus_dose_from_cmax Calculate dose to achieve steady state Cmax for 2-compartmental PK model bolus dosing at steady state
pk_2cmt_bolus_dose_from_cmin Calculate dose to achieve steady state trough for 2-compartmental PK model bolus dosing at steady state
pk_2cmt_bolus_ss Concentration predictions for 2-compartmental PK model, bolus dosing at steady state
pk_2cmt_inf Concentration predictions for 2-compartmental PK model, single or multiple infusions
pk_2cmt_inf_cmax_ss Cmax (trough) for 2-compartmental PK model, bolus dosing at steady state
pk_2cmt_inf_cmin_ss Cmin (trough) for 2-compartmental PK model, bolus dosing at steady state
pk_2cmt_inf_dose_from_cmax Calculate dose to achieve steady state Cmax for 2-compartmental PK model with infusion dosing at steady state
pk_2cmt_inf_dose_from_cmin Calculate dose to achieve steady state trough for 2-compartmental PK model with infusion dosing at steady state
pk_2cmt_inf_ss Concentration predictions for 2-compartmental PK model with infusion dosing at steady state
pk_2cmt_t12 Calculate half-life(s) for 2-compartment model
pk_2cmt_t12_interval Calculate average half-life for 2-compartment model during a specific interval
read_who_table Read WHO growth tables
relative2absolute_bsa Convert quantity expressed relative to BSA to absolute units
time_to_ss Time to steady state In either time units or number of doses
valid_units Valid units
weight2kg Convert any weight unit to kg