calc_aki_stage {clinPK} | R Documentation |
Calculate AKI stage
Description
Calculate AKI class based on serum creatinine values over time, using various methods for children (pRIFLE) and adults (RIFLE, kDIGO)
Usage
calc_aki_stage(
scr = NULL,
times = NULL,
method = "kdigo",
baseline_scr = "median",
baseline_egfr = NULL,
first_dose_time = NULL,
age = NULL,
egfr = NULL,
egfr_method = NULL,
force_numeric = FALSE,
override_prifle_baseline = FALSE,
verbose = TRUE,
return_object = TRUE,
...
)
Arguments
scr |
serum creatinine in mg/dL. Use 'convert_creat()' to convert from mmol/L. Values below the detection limit ("<0.2") will be converted to numeric (0.2) |
times |
creatinine sample times in hours |
method |
classification method, one of 'KDIGO', 'RIFLE', 'pRIFLE' (case insensitive) |
baseline_scr |
baseline serum creatinine, required for 'RIFLE' classifation. Will use value if numeric. If 'character', can be either 'median', 'median_before_treatment', 'lowest', or 'first'. |
baseline_egfr |
baseline eGFR, required for 'RIFLE' classifations. Will take median of 'egfr' values if 'NULL'. |
first_dose_time |
time in hours of first dose relative to sCr value, used for calculate baseline serum creatinine in 'median_before_treatment' approach. |
age |
age in years, needed when eGFR is used in the classification method |
egfr |
eGFR in ml/min/1.73m^2. Optional, can also be calcualted if 'age', 'weight', 'height', 'sex', 'egfr_method' are specified as arguments. |
egfr_method |
eGFR calculation method, used by 'calc_egfr()'. If NULL, will pick default based on classification system ('cockroft_gault' for RIFLE / kDIGO, 'revised_schwartz' for pRIFLE). |
force_numeric |
keep stage numeric (1, 2, or 3), instead of e.g. "R", "I", "F" as in RIFLE. Default 'FALSE'. |
override_prifle_baseline |
by default, 'pRIFLE' compares eGFR to 120 ml/min. Override by setting to TRUE. |
verbose |
verbose ('TRUE' or 'FALSE') |
return_object |
return object with detailed data (default 'TRUE'). If 'FALSE', will just return maximum stage. |
... |
arguments passed on to 'calc_egfr()' |
References
-
pRIFLE: Ackan-Arikan et al. "Modified RIFLE criteria in critically ill children with acute kidney injury." Kidney Int. (2007)
-
RIFLE: Bellomo et al. "Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group." Critical Care. (2004)
-
KDIGO: Khwaja. "KDIGO clinical practice guidelines for acute kidney injury." Nephron Clinical Practice. (2012)
-
pRIFLE baseline eGFR: Soler et al. "pRIFLE (Pediatric Risk, Injury, Failure, Loss, End Stage Renal Disease) score identifies Acute Kidney Injury and predicts mortality in critically ill children : a prospective study." Pediatric Critical Care Medicine. (2014)
Examples
calc_aki_stage(
scr = c(0.7, 0.9, 1.8, 1.5),
t = c(0, 40, 100, 130),
age = 50, weight = 60,
height = 170, sex = "female")