calc_kel_single_tdm {clinPK}

Calculate elimination rate when given a single TDM sample

Description

Using iterative k_el calculation, and based on given Volume

Usage

calc_kel_single_tdm(
  dose = 1000,
  V = 50,
  t = 10,
  dv = 10,
  tau = 12,
  t_inf = 1,
  kel_init = 0.1,
  n_iter = 25,
  learn_rate = 0.2
)

Arguments

dose

dose amount

V

volume of distribution

t

time or time after dose

dv

observed value

tau

dosing interval

t_inf

infusion time

kel_init

estimate of elimination rate

n_iter

number of iterations to improve estimate of elimination rate

learn_rate

default is 0.2

Examples

calc_kel_single_tdm(dose = 1000, t = 18)