pk_2cmt_inf_dose_from_cmax {clinPK}R Documentation

Calculate dose to achieve steady state Cmax for 2-compartmental PK model with infusion dosing at steady state

Description

Calculate dose to achieve steady state Cmax for 2-compartmental PK model with infusion dosing at steady state

Usage

pk_2cmt_inf_dose_from_cmax(cmax = 1, tau = 12, t_inf = 1, CL = 3,
  V = 30, Q = 2, V2 = 20)

Arguments

cmax

desired trough concentration

tau

dosing interval

t_inf

infusion time

CL

clearance

V

volume of distribution

Q

inter-compartimental clearance

V2

volume of peripheral compartment

Examples

dos <- pk_2cmt_inf_dose_from_cmax(
  cmax = 25, tau = 12, t_inf = 2,
  CL = 5, V = 50, Q = 20, V2 = 200)
find_nearest_dose(dos, 100)

[Package clinPK version 0.9.0 Index]