pk_2cmt_inf_dose_from_cmax {clinPK} | R Documentation |
Calculate dose to achieve steady state Cmax for 2-compartmental PK model with infusion dosing at steady state
pk_2cmt_inf_dose_from_cmax(
cmax = 1,
tau = 12,
t_inf = 1,
CL = 3,
V = 30,
Q = 2,
V2 = 20
)
cmax |
desired trough concentration |
tau |
dosing interval |
t_inf |
infusion time |
CL |
clearance |
V |
volume of distribution |
Q |
inter-compartimental clearance |
V2 |
volume of peripheral compartment |
dos <- pk_2cmt_inf_dose_from_cmax(
cmax = 25, tau = 12, t_inf = 2,
CL = 5, V = 50, Q = 20, V2 = 200)
find_nearest_dose(dos, 100)