calc_carboplatin_calvert {clinPK}

Calvert equation for carboplatin

Description

The Calvert equation calculates a dose expected to bring the patient to the target AUC given their glomerular filtration rate (GFR). The original equation was developed on a data set of 18 individuals with GFR of 33-136 ml/min.

Usage

calc_carboplatin_calvert(target_auc, gfr = NULL, ...)

Arguments

target_auc

target AUC, in mg/ml-min, typically between 2-8 mg/ml-min

gfr

glomerular filtration rate, in ml/min. See also 'clinPK::calc_egfr'.

...

arguments passed on to 'calc_egfr' if gfr is not supplied

References

Calvert et al., Journal of Clinical Oncology (1976)

Examples

calc_carboplatin_calvert(5, 100)
calc_carboplatin_calvert(4, 30)
calc_carboplatin_calvert(2, sex = "male", age = 50, scr = 1.1, weight = 70)