pk_2cmt_inf_dose_from_cmin {clinPK} | R Documentation |
Calculate dose to achieve steady state trough for 2-compartmental PK model with infusion dosing at steady state
pk_2cmt_inf_dose_from_cmin(cmin = 1, tau = 12, t_inf = 1, CL = 3, V = 30, Q = 2, V2 = 20)
cmin |
desired trough concentration |
tau |
dosing interval |
t_inf |
infusion time |
CL |
clearance |
V |
volume of distribution |
Q |
inter-compartimental clearance |
V2 |
volume of peripheral compartment |
dos <- pk_2cmt_inf_dose_from_cmin( cmin = 10, tau = 12, t_inf = 2, CL = 5, V = 50, Q = 20, V2 = 200) find_nearest_dose(dos, 100)