pk_1cmt_inf_dose_for_range {clinPK}

Calculate dose based on a given AUC24, Cmax, and Cmin, assuming 1-compartment model

Description

Calculate dose based on a given AUC24, Cmax, and Cmin, assuming 1-compartment model

Usage

pk_1cmt_inf_dose_for_range(
  target = 500,
  type = "auc",
  conc_range = c(10, 40),
  parameters = list(),
  interval = 24,
  t_inf = 1,
  optimize_interval = TRUE,
  round_interval = TRUE
)

Arguments

target

numeric value of target

type

target type, one of 'auc', 'auc24', 'ctrough', 'cmin'

conc_range

concentration range to stay within, vector of length 2

parameters

list of 'CL' and 'V', or 'KEL' and 'CL'

interval

dosing interval

t_inf

infusion time

optimize_interval

find optimal interval (to stay within 'conc_range'?

round_interval

round interval to nearest nominal interval?