calc_ffm {clinPK}

Calculate fat-free mass

Description

Get an estimate of fat-free mass (FFM, in kg) based on weight, height, and sex (and age for Storset equation).

Usage

calc_ffm(
  weight = NULL,
  bmi = NULL,
  sex = NULL,
  height = NULL,
  age = NULL,
  method = c("janmahasatian", "green", "al-sallami", "storset", "bucaloiu", "hume",
    "james", "garrow_webster"),
  digits = 1
)

Arguments

weight

total body weight in kg

bmi

BMI, only used in 'green' method. If 'weight' and 'height' are both specified, 'bmi' will be calculated on-the-fly.

sex

sex, either 'male' of 'female'

height

height in cm, only required for 'holford' method, can be used instead of 'bmi' for 'green' method

age

age, only used for Storset equation

method

estimation method, one of 'janmahasatian' (default), 'green', 'al-sallami', 'storset', 'bucaloiu', 'hume', 'james', or 'garrow_webster'.

digits

round to number of digits

Details

References: 'janmahasatian', 'green': Janmahasatian et al. Clin Pharmacokinet. 2005;44(10):1051-65) 'al-sallami': Al-Sallami et al. Clin Pharmacokinet 2015 'storset': Storset E et al. TDM 2016 'bucaloiu': Bucaloiu ID et al. Int J of Nephrol Renovascular Dis. 2011 (Morbidly obese females) 'hume': Hume R. J Clin Pathol 1966 'james': James WPT et al. Research on obesity: a report of the DHSS/MRC Group 1976 ‘garrow_webster': Garrow JS, Webster J. Quetelet’s index (W/H2) as a measure of fatness. Int J Obesity 1984

Overview: - Sinha J, Duffull1 SB, Al-Sallami HS. Clin Pharmacokinet 2018. https://doi.org/10.1007/s40262-017-0622-5

Value

Returns a list of the following elements:

value

Fat-free Mass (FFM) in units of kg

unit

Unit describing FFM, (kg)

method

Method used to calculate FFF

Examples

calc_ffm(weight = 70, bmi = 25, sex = "male")
calc_ffm(weight = 70, height = 180, age = 40, sex = "female", method = "storset")