Target Controlled Infusion (TCI)

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Documentation for package ‘tci’ version 0.2.0

• DESCRIPTION file.
• User guides, package vignettes and other documentation.

Help Pages

apply_tci	Apply a TCI algorithm to a 'pkmod' object
assign_pars	Set default PK parameter values Set default PK parameter values for a pkmod object.
bayes_update	Update PK-PD model parameters using observed data values
clc	Simulate closed-loop control
eleveld_pd	Eleveld et al. pharmacodynamic data
eleveld_pk	Eleveld et al. pharmacokinetic data
elvdlpars	Get logged parameters updated in Eleveld model
emax	Emax function
emax_eleveld	Emax function for Eleveld (2018) model.
emax_inv	Inverse Emax function
emax_inv_eleveld	Inverse Emax function
emax_inv_remi	Inverse Emax function implemented by Eleveld remifentanil model
emax_remi	Emax function implemented by Eleveld remifentanil model
format_pars	Format parameters for use in Rcpp functions Order parameters for 1-4 compartment models to be used in Rcpp functions in predict_pkmod method.
infer_pkfn	Identify pkfn from parameter names
inf_manual	infusion schedule
inf_tci	Target-controlled infusion
init_pkmod	Create an object with class "pkmod"
init_poppkmod	Initialize a 'poppkmod' object.
list_parnms	Identify pkfn from parameter names
list_pkmods	Print population PK models available in 'tci'
log_likelihood	Evaluate the log likelihood of a vector of parameter values
log_posterior_neg	Evaluate the negative log posterior value of a parameter vector
log_prior	Calculate logged-prior probability for a set of parameters
olc	Simulate open-loop control
pkmod	Create a pkmod object
pkmod1cpt	One compartment IV infusion with first-order elimination.
pkmod2cpt	Two compartment IV infusion with first-order elimination.
pkmod3cpt	Three compartment IV infusion with first-order elimination.
pkmod3cptm	Solution to three-compartment IV model with effect-site
pkmod_eleveld_ppf	Eleveld population PK model for propofol
pkmod_eleveld_remi	Eleveld population PK model for remifentanil
pkmod_kim	Kim population PK model for remifentanil
pkmod_marsh	--- Population PK and PK-PD functions -- --- Marsh population PK model for propofol
pkmod_minto	Minto population PK model for remifentanil
pkmod_schnider	Schnider population PK model for propofol
plot.sim_tci	Plot method for sim_tci class
poppkmod	Implement a population pharmacokinetic/pharmacodynamic model.
predict.pkmod	Predict method for pkmod objects
predict.poppkmod	Predict method for pkmod objects
print.pkmod	Print pkmod
print.poppkmod	Print poppkmod
print.sim_tci	Print method for sim_tci class
sample_iiv	Sample PK or PK-PD parameters from the distribution of inter- or intra-individual variability
sample_pkmod	Sample parameters from a 'pkmod' object
simulate.pkmod	Simulate method for pkmod objects
simulate.poppkmod	Summary method for 'poppkmod' objects
simulate_clc	Simulate closed-loop control using Bayesian updates
simulate_olc	Simulate open-loop control using TCI
simulate_tci	Simulate open- or closed-loop control
tci_documentation	tci_documentation
tci_effect	Effect-site TCI algorithm with plasma targeting within small range of target
tci_effect_only	TCI algorithm for effect-site targeting
tci_plasma	TCI algorithm for plasma targeting
update.pkmod	Update method for pkmod
validate_pkmod	pkmod validation checks
validate_poppkmod	Perform validation checks on a 'poppkmod' object