apply_tci |
Apply a TCI algorithm to a 'pkmod' object |
assign_pars |
Set default PK parameter values Set default PK parameter values for a pkmod object. |
bayes_update |
Update PK-PD model parameters using observed data values |
clc |
Simulate closed-loop control |
eleveld_pd |
Eleveld et al. pharmacodynamic data |
eleveld_pk |
Eleveld et al. pharmacokinetic data |
elvdlpars |
Get logged parameters updated in Eleveld model |
emax |
Emax function |
emax_eleveld |
Emax function for Eleveld (2018) model. |
emax_inv |
Inverse Emax function |
emax_inv_eleveld |
Inverse Emax function |
emax_inv_remi |
Inverse Emax function implemented by Eleveld remifentanil model |
emax_remi |
Emax function implemented by Eleveld remifentanil model |
format_pars |
Format parameters for use in Rcpp functions Order parameters for 1-4 compartment models to be used in Rcpp functions in predict_pkmod method. |
infer_pkfn |
Identify pkfn from parameter names |
inf_manual |
infusion schedule |
inf_tci |
Target-controlled infusion |
init_pkmod |
Create an object with class "pkmod" |
init_poppkmod |
Initialize a 'poppkmod' object. |
list_parnms |
Identify pkfn from parameter names |
list_pkmods |
Print population PK models available in 'tci' |
log_likelihood |
Evaluate the log likelihood of a vector of parameter values |
log_posterior_neg |
Evaluate the negative log posterior value of a parameter vector |
log_prior |
Calculate logged-prior probability for a set of parameters |
olc |
Simulate open-loop control |
pkmod |
Create a pkmod object |
pkmod1cpt |
One compartment IV infusion with first-order elimination. |
pkmod2cpt |
Two compartment IV infusion with first-order elimination. |
pkmod3cpt |
Three compartment IV infusion with first-order elimination. |
pkmod3cptm |
Solution to three-compartment IV model with effect-site |
pkmod_eleveld_ppf |
Eleveld population PK model for propofol |
pkmod_eleveld_remi |
Eleveld population PK model for remifentanil |
pkmod_kim |
Kim population PK model for remifentanil |
pkmod_marsh |
--- Population PK and PK-PD functions -- --- Marsh population PK model for propofol |
pkmod_minto |
Minto population PK model for remifentanil |
pkmod_schnider |
Schnider population PK model for propofol |
plot.sim_tci |
Plot method for sim_tci class |
poppkmod |
Implement a population pharmacokinetic/pharmacodynamic model. |
predict.pkmod |
Predict method for pkmod objects |
predict.poppkmod |
Predict method for pkmod objects |
print.pkmod |
Print pkmod |
print.poppkmod |
Print poppkmod |
print.sim_tci |
Print method for sim_tci class |
sample_iiv |
Sample PK or PK-PD parameters from the distribution of inter- or intra-individual variability |
sample_pkmod |
Sample parameters from a 'pkmod' object |
simulate.pkmod |
Simulate method for pkmod objects |
simulate.poppkmod |
Summary method for 'poppkmod' objects |
simulate_clc |
Simulate closed-loop control using Bayesian updates |
simulate_olc |
Simulate open-loop control using TCI |
simulate_tci |
Simulate open- or closed-loop control |
tci_documentation |
tci_documentation |
tci_effect |
Effect-site TCI algorithm with plasma targeting within small range of target |
tci_effect_only |
TCI algorithm for effect-site targeting |
tci_plasma |
TCI algorithm for plasma targeting |
update.pkmod |
Update method for pkmod |
validate_pkmod |
pkmod validation checks |
validate_poppkmod |
Perform validation checks on a 'poppkmod' object |