pkmod2cpt {tci}

Two compartment IV infusion with first-order elimination.

Description

Two compartment IV infusion with first-order elimination. Elimination from peripheral compartment is assumed to be zero unless 'k20' is specified.

Usage

pkmod2cpt(tm, kR, pars, init = c(0, 0))

Arguments

tm

Vector of times to evaluate the PK function at

kR

Infusion rate (e.g. ml/min).

pars

Named vector of parameters with names ('K10','K12','K21','V1','V2') or ('CL','Q','V1','V2').

init

Initial concentration. Defaults to 0 in both compartments.

Value

Numeric matrix of concentrations for a constant infusion rate

Examples

pkmod2cpt(1,1,c(CL = 15, V1 = 10, Q2 = 10, V2 = 20))
pkmod2cpt(1,1,c(CL = 15, v1 = 10, Q2 = 10, V2 = 20, cl2 = 4))