eleveld_pd {tci}

Eleveld et al. pharmacodynamic data

Description

Empirical Bayes (EB) estimates of PD parameters made by the Eleveld et al (2018) PK-PD model. EB estimates were calculated using the PK-PD datasets and NONMEM files provided by Eleveled et al. (2018). The original datasets were obtained through the Open TCI Initiative website (opentci.org) and based on contributions from a number of researchers who made their datasets publically available.

Usage

data(eleveld_pd)

Format

A data frame with 122 rows and 15 variables:

ID

Patient ID

E50

EB estimate of effect-site concentration required to achieve 50 percent response

KE0

EB estimate of elimination rate from effect-site compartment

EMAX

EB estimate of baseline bispectral index (BIS) with no drug administered

GAM

EB estimate of Hill parameter when the effect-site concentration is less than E50

GAM1

EB estimate of Hill parameter when the effect-site concentration is greater than than E50

RESD

EB estimate of residual error term

ALAG1

Estimated time lag in BIS measurements due to patient age (fixed-effects only)

AGE

Patient's age (years)

WGT

Patient's weight (kg)

HGT

Patient's height (cm)

M1F2

Patient's sex: male = 1, female = 2

A1V2

Sampling site: arterial sampling = 1, venous sampling = 2

PMA

Patient's post-menstrual age. Assumed to be age + 40 weeks if not provided

TECH

Presence of concomitant anaesthetic techniques (Local anesthetic = 1, Opioids = 2)

References

Eleveld et al. (2018) British Journal of Anesthesia Vol. 120, 5:942-959 (BJA)