| eleveld_pk {tci} | R Documentation |
Eleveld et al. pharmacokinetic data
Description
Empirical Bayes (EB) estimates of PK parameters for the Eleveld et al. (2018) PK-PD model. EB estimates were calculated using the PK-PD datasets and NONMEM files provided by Eleveled et al. (2018). The original datasets were obtained through the Open TCI Initiative website (opentci.org) and based on contributions from a number of researchers who made their datasets publically available.
Usage
data(eleveld_pk)
Format
A data frame with 1033 rows and 16 variables:
- ID
Patient ID
- V1
EB estimate of first compartment volume
- V2
EB estimate of second compartment volume
- V3
EB estimate of third compartment volume
- CL
EB estimate of clearance for the first compartment
- Q2
EB estimate of inter-compartmental clearance for second compartment
- Q3
EB estimate of inter-compartmental clearance for third compartment
- AGE
Patient's age (years)
- WGT
Patient's weight (kg)
- HGT
Patient's height (cm)
- M1F2
Patient's sex: male = 1, female = 2
- PMA
Patient's post-menstrual age. Assumed to be age + 40 weeks if not provided
- TECH
Presence of concomitant anaesthetic techniques (Local anesthetic = 1, Opioids = 2)
- BMI
Patient's BMI
- FFM
Patient's fat-free mass (FFM)
- A1V2
Sampling site: arterial sampling = 1, venous sampling = 2
References
Eleveld et al. (2018) British Journal of Anesthesia Vol. 120, 5:942-959 (BJA)