tci_effect_only {tci}

TCI algorithm for effect-site targeting

Description

Function for calculating a TCI infusion schedule corresponding to a set of target concentrations. This function makes use of formulas described by Shafer and Gregg (1992) in "Algorithms to rapidly achieve and maintain stable drug concentrations at the site of drug effect with a computer-controlled infusion pump"

Usage

tci_effect_only(
  Ct,
  pkmod,
  dtm = 1/6,
  tmax_search = 10,
  maxrt = 1200,
  grid_len = 1200,
  ...
)

Arguments

Ct

Numeric vector of target effect-site concentrations.

pkmod

PK model

dtm

Frequency of TCI updates. Default is 1/6 minutes = 10 seconds.

tmax_search

Outer bound on times searched to find a maximum concentration following an infusion of duration dtm. Defaults to 20 minutes. May need to be increased if a drug has a slow elimination rate.

maxrt

Maximum infusion rate of TCI pump. Defaults to 1200.

grid_len

Number of time points used to identify time of maximum concentration. Can be increased for more precision.

...

List or vector of named values to be passed on to update.pkmod.

Value

Numeric value

Examples

# three compartment model with effect site
my_mod <- pkmod(pars_pk = c(v1 = 8.995, v2 = 17.297, v3 = 120.963,
cl = 1.382, q2 = 0.919, q3 = 0.609, ke0 = 1.289))
tci_effect_only(Ct = 2, pkmod = my_mod)
# update parameters
tci_effect_only(Ct = 2, pkmod = my_mod, pars_pk = c(v1 = 12, cl = 2))