sample_iiv {tci} | R Documentation |
Sample PK or PK-PD parameters from the distribution of inter- or intra-individual variability
Description
Sample PK or PK-PD parameters from the distribution of random effects for a 'pkmod' or 'poppkmod' object, as described by the Omega matrix (see ?pkmod).
Usage
sample_iiv(mod, log_normal = TRUE, ...)
Arguments
mod |
'pkmod' or 'poppkmod' object with associated Omega matrix describing random effect variances |
log_normal |
Logical. Assumes random effects are log-normally distributed and multiplicative if TRUE, additive and normally distributed if FALSE. |
... |
Arguments passed to update.pkmod. |
Value
Returns model passed to "mod" argument with randomly sampled PK or PK-PD parameters.
Examples
# sample from single PK model
sample_iiv(pkmod_schnider(AGE = 40,HGT=170,TBW=50,MALE=TRUE))
# sample from `poppkmod`
data <- data.frame(ID = 1:5, AGE = seq(20,60,by=10), TBW = seq(60,80,by=5),
HGT = seq(150,190,by=10), MALE = c(TRUE,TRUE,FALSE,FALSE,FALSE))
sample_iiv(poppkmod(data = data, drug = "ppf", model = "eleveld"))
[Package tci version 0.2.0 Index]