tci_plasma {tci}

TCI algorithm for plasma targeting

Description

TCI algorithm based on the algorithm described by Jacobs (1990).

Usage

tci_plasma(Ct, pkmod, dtm = 1/6, maxrt = 1200, ...)

Arguments

Ct

Target plasma concentration

pkmod

PK model

dtm

Duration of the infusion

maxrt

Maximum infusion rate. Defaults to 200 ml/min in reference to the maximum infusion rate of 1200 ml/h permitted by existing TCI pumps (e.g. Anestfusor TCI program).

...

Arguments passed on to update.pkmod.

Value

Numeric value

Examples

# plasma targeting
my_mod <- pkmod(pars_pk = c(CL = 10, V1 = 10))
tci_plasma(Ct = 2, my_mod)
# update CL parameter
tci_plasma(Ct = 2, my_mod, pars_pk = c(CL = 15))