Deconvolution of Bulk RNA-Seq Data using Single-Cell RNA-Seq Data as Reference


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Documentation for package ‘SCdeconR’ version 1.0.0

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bulk_generator Generate artificial bulk RNA-seq samples based on simulation
celltype_expression Compute cell type specific gene expression
comparedeg_scatter Generate a scatter plot comparing two differential expression results
comparegsea_scatter Generate a scatter plot comparing two gene set enrichment analysis results
compute_metrics Statistical evaluations of predicted cell proportions
construct_ref Integration of single-cell/nuclei RNA-seq data as reference
gsea_heatmap Heatmap to demonstrate enrichment of selected gene-sets
gsea_rwplot GSEA random-walk plot
gsea_sumplot Summary plot of gene set enrichment analysis
load_scdata Load, filter and normalize scRNA-seq/snRNA-seq data
prepare_rnk Prepare .rnk file for GSEA preranked analysis
prop_barplot Bar plot of cell type proportions across samples
read_gmt Methods to manipulate .gmt files
reformat_gmt Methods to manipulate .gmt files
run_de Differential expression analysis
scaling Normalization of gene expression data
scdecon Deconvolution of bulk RNA-seq data
transformation Transformation of gene expression data
write_gmt Methods to manipulate .gmt files