Dose Titration Algorithm Tuning


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Documentation for package ‘DTAT’ version 0.3-6

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DTAT-package Dose Titration Algorithm Tuning: a Framework for Dose Individualization in Drug Development
as_d3_data-method Convert a DE object to JSON
DE-class An S4 class for simulating dose-titration study designs
de.bioRxiv.240846 Simulated '3+3/PC' dose-titration study from bioRxiv paper no. 240846
dose.survfit Calculate a dose-survival curve from a dose titration study, adding a confidence band
dose.survival Extract interval-censored dose tolerance data from a dose titration study
ds.curve Extract the dose-survival curve, with its upper and lower confidence band limits
DTAT Dose Titration Algorithm Tuning: a Framework for Dose Individualization in Drug Development
dtat1000 Precomputed neutrophil-guided chemotherapy dose titration for 1000 simulated subjects.
newton.raphson A dose titration algorithm (DTA) 'factory' based on the Newton-Raphson heuristic
Onoue.Friberg POMP PK/PD model for docetaxel, combining Onoue et al (2016) with Friberg et al (2002)
plot-method Plot a DE object as an interactive htmlwidget
runDTATapp Run Shiny apps included in package DTAT
scaled Power-law scaling for doses
seq.function A seq method supporting custom-scaled plot axes.
sim Environment for simulation global variables.
titrate Perform neutrophil-guided dose titration of a chemotherapy drug.
titration Simulate a '3+3/PC' dose-titration trial
titration-method Simulate a '3+3/PC' dose-titration trial