Dose Titration Algorithm Tuning

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Documentation for package ‘DTAT’ version 0.3-7

• DESCRIPTION file.
• User guides, package vignettes and other documentation.

Help Pages

DTAT-package	Dose Titration Algorithm Tuning: a Framework for Dose Individualization in Drug Development
as_d3_data-method	Convert a DE object to JSON
DE-class	An S4 class for simulating dose-titration study designs
de.bioRxiv.240846	Simulated '3+3/PC' dose-titration study from bioRxiv paper no. 240846
dose.survfit	Calculate a dose-survival curve from a dose titration study, adding a confidence band
dose.survival	Extract interval-censored dose tolerance data from a dose titration study
ds.curve	Extract the dose-survival curve, with its upper and lower confidence band limits
DTAT	Dose Titration Algorithm Tuning: a Framework for Dose Individualization in Drug Development
dtat1000	Precomputed neutrophil-guided chemotherapy dose titration for 1000 simulated subjects.
newton.raphson	A dose titration algorithm (DTA) 'factory' based on the Newton-Raphson heuristic
Onoue.Friberg	POMP PK/PD model for docetaxel, combining Onoue et al (2016) with Friberg et al (2002)
plot-method	Plot a DE object as an interactive htmlwidget
runDTATapp	Run Shiny apps included in package DTAT
scaled	Power-law scaling for doses
seq.function	A seq method supporting custom-scaled plot axes.
sim	Environment for simulation global variables.
titrate	Perform neutrophil-guided dose titration of a chemotherapy drug.
titration	Simulate a '3+3/PC' dose-titration trial
titration-method	Simulate a '3+3/PC' dose-titration trial