newton.raphson {DTAT}

A dose titration algorithm (DTA) 'factory' based on the Newton-Raphson heuristic

Description

This higher-order ('factory') function produces a simple dose titration algorithm for neutrophil-guided chemotherapy dosing.

Usage

newton.raphson(dose1, omega, slope1, slopeU)

Arguments

dose1

The starting dose for titration

omega

A relaxation parameter used to moderate dose increments

slope1

Dose-response slope assumed prior to 2nd measured neutrophil nadir

slopeU

Upper bound imposed on slope estimates

Details

This function manifests the core concept of Dose Titration Algorithm Tuning by delivering an objectively realized 'DTA'. It therefore enables a variety of DTAs to be implemented and compared.

Value

A dose titration function that advises dose for next cycle of chemotherapy.

Author(s)

David C. Norris

See Also

titrate