titration {DTAT}

Simulate a ‘3+3/PC’ dose-titration trial

Description

Simulate a ‘3+3/PC’ dose-titration trial

Usage

titration(x, periods, ...)

## S4 method for signature 'DE,numeric'
titration(x, periods, ...)

Arguments

x

An object of S4 class DE

periods

The number of DLT assessment periods to titrate over. Should be a positive integer.

...

May be used to pass verbatim = 'TRUE' to internal step_time method.

References

Norris DC. Precautionary Coherence Unravels Dose Escalation Designs. bioRxiv. December 2017:240846. doi:10.1101/240846. https://www.biorxiv.org/content/10.1101/240846v1