Simulation and Group Sequential Monitoring of Randomized Two-Stage Treatment Efficacy Trials with Time-to-Event Endpoints

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Documentation for package ‘seqDesign’ version 1.2

• DESCRIPTION file.
• User guides, package vignettes and other documentation.

Help Pages

censTrial	Generation of Pre-Unblinded Follow-Up Data-Sets by Applying the Monitoring Outcomes
getBlockSize	Determine block size for use in blocked randomization
monitorTrial	Group Sequential Monitoring of Simulated Efficacy Trials for the Event of Potential Harm, Non-Efficacy, and High Efficacy
rankTrial	Ranking and Selection, and Head-to-Head Comparison of Individual and Pooled Treatment Arms
simTrial	Simulation of Multi-Arm Randomized Phase IIb/III Efficacy Trials with Time-to-Event Endpoints
VEpowerPP	Unconditional Power to Detect Positive Treatment Efficacy in a Per-Protocol Cohort