Adaptive Enrichment Designs with Sample Size Re-Estimation

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Documentation for package ‘esDesign’ version 1.0.3

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AED.boundary Calculate the critical value used at the final analysis in AED
AED.sim Conduct the simulation studies of the Adaptive Enrichment Design without early stopping boundary
AED1_SSR.boundary Calculate the critical value used at the final analysis of the Adaptive Enrichment Design (Strategy 1) with Sample Size Re-estimation Procedure
AED1_SSR.CP Calculate the conditional power of the Adaptive Enrichment Design with (Strategy 1) Sample Size Re-estimation Procedure
AED1_SSR.N2 Calculate the sample size required at the second stage of the adaptive enrichment design (Strategy1) with Sample Size Re-estimation Procedure
AED1_SSR.sim Conduct the simulation studies of the Adaptive Enrichment Design (Strategy 1) with Sample Size Re-estimation Procedure
AED2_SSR.boundary Calculate the futility and efficacy stopping boundaries of the Adaptive Enrichment Design (Strategy 2) with Sample Size Re-estimation Procedure
AED2_SSR.CP Calculate the N2 and the critical value C in the Adaptive Enrichment Design (Strategy 2) with Sample Size Re-estimation Procedure
AED2_SSR.sim Conduct the simulation studies of the Adaptive Enrichment Design (Strategy 2) with Sample Size Re-estimation Procedure
AED3_SSR.boundary Calculate the futility and efficacy stopping boundaries in Adaptive enrichment design (Strategy 3) with Sample Size Re-estimation Procedure for the continuous endpoint
AED3_SSR.CP Calculate the N2 and the critical value C in the Adaptive Enrichment Design (Strategy 3) with Sample Size Re-estimation Procedure
AED3_SSR.sim Conduct the simulation studies of the Adaptive Enrichment Design (Strategy 3) with Sample Size Re-estimation Procedure based on Futility and Efficacy Stopping Boundaries for the continuous endpoint
MaST.sim Conduct the simulation studies of the Marker Sequential Test design
SD.sim Conduct the simulation studies of the standard design
SigP Commonly used alpha-spending functions
sSize.norm Sample size calculation for the standard design with continuous endpoint
SSR.boundary Calculate the futility and efficacy stopping boundaries for Sample Size Re-estimation Procedure based on the conditional error function
SSR.CP Calculate the N2 and the critical value C in Sample Size Re-estimation Procedure
SSR.sim Conduct the simulation studies using SSR