AED.boundary |
Calculate the critical value used at the final analysis in APE |

AED.sim |
Conduct the simulation studies of the Adaptive Enrichment Design without early stopping boundary |

AED1_SSR.boundary |
Calculate the critical value used at the final analysis of the Adaptive Enrichment Design (Strategy 1) with Sample Size Re-estimation Procedure |

AED1_SSR.CP |
Calculate the conditional power of the Adaptive Enrichment Design with (Strategy 1) Sample Size Re-estimation Procedure |

AED1_SSR.N2 |
Calculate the sample size required at the second stage of the adaptive enrichment design (Strategy1) with Sample Size Re-estimation Procedure |

AED1_SSR.sim |
Conduct the simulation studies of the Adaptive Enrichment Design (Strategy 1) with Sample Size Re-estimation Procedure |

AED2_SSR.boundary |
Calculate the futility and efficacy stopping boundaries of the Adaptive Enrichment Design (Strategy 2) with Sample Size Re-estimation Procedure |

AED2_SSR.CP |
Calculate the N2 and the critical value C in the Adaptive Enrichment Design (Strategy 2) with Sample Size Re-estimation Procedure |

AED2_SSR.sim |
Conduct the simulation studies of the Adaptive Enrichment Design (Strategy 2) with Sample Size Re-estimation Procedure |

AED3_SSR.boundary |
Calculate the futility and efficacy stopping boundaries in Adaptive enrichment design (Strategy 3) with Sample Size Re-estimation Procedure for the continuous endpoint |

AED3_SSR.CP |
Calculate the N2 and the critical value C in the Adaptive Enrichment Design (Strategy 3) with Sample Size Re-estimation Procedure |

AED3_SSR.sim |
Conduct the simulation studies of the Adaptive Enrichment Design (Strategy 3) with Sample Size Re-estimation Procedure based on Futility and Efficacy Stopping Boundaries for the continuous endpoint |

MaST.sim |
Conduct the simulation studies of the Marker Sequential Test design |

SD.sim |
Conduct the simulation studies of the standard design |

SigP |
Commonly used alpha-spending functions |

sSize.norm |
Sample size calculation for the standard design with continuous endpoint |

SSR.boundary |
Calculate the futility and efficacy stopping boundaries for Sample Size Re-estimation Procedure based on the conditional error function |

SSR.CP |
Calculate the N2 and the critical value C in Sample Size Re-estimation Procedure |

SSR.sim |
Conduct the simulation studies using SSR |