AED.boundary {esDesign}

Calculate the critical value used at the final analysis in AED

Description

AED.boundary() is used to calculate the critical value used at the final analysis in AED design, meanwhile preserving the overall type I error rate at \alpha level

Usage

AED.boundary(rho, alpha, Info, epsilon)

Arguments

rho

The proportion of subgroup 1

alpha

The overall type I error rate

Info

The infromation fraction

epsilon

The threshold of difference between the subgroup-specific test statistics

Value

The critical value used at the final analysis

References

• Lin, R., Yang, Z., Yuan, Y. and Yin, G., 2021. Sample size re-estimation in adaptive enrichment design. Contemporary Clinical Trials, 100, p.106216. <doi: 10.1016/j.cct.2020.106216>

Examples

AED.boundary(rho = 0.5, alpha = 0.05, Info = 0.5, epsilon = 0.5)