xlink {xlink} | R Documentation |
xlink: A package for genetic association models for X-chromosome SNPS on continuous, binary and survival outcomes.
Description
The expression of X-chromosome undergoes three possible biological processes: X-chromosome inactivation (XCI), escape of the X-chromosome inactivation (XCI-E),and skewed X-chromosome inactivation (XCI-S). To analyze the X-linked genetic association for phenotype such as continuous, binary, and time-to-event outcomes with the actual process unknown, we propose a unified approach of maximizing the likelihood or partial likelihood over all of the potential biological processes.
xlink functions
xlink_fit, select_output.
References
Xu, Wei, and Meiling Hao. 'A unified partial likelihood approach for X-chromosome association on time-to-event outcomes.' Genetic epidemiology 42.1 (2018): 80-94.
[Package xlink version 1.0.1 Index]