MC4_Methods {tcpl} | R Documentation |
List of level 4 multiple-concentration methods for calculating bmad
Description
mc4_mthds
returns a list of methods to be used
during level 4 multiple-concentration processing for calculating bmad
Usage
mc4_mthds()
Details
The functions contained in the list returned by mc4_mthds
take
aeids
(a numeric vector of aeid values) and returns a list of expressions
to be executed in the mc4
(not exported) function environment. The
functions are described here for reference purposes, The
mc4_mthds
function is not exported, nor is it intended for use.
All available methods are described in the Available Methods section, listed by the type of function and the function/method name.
Value
A list of functions
Available Methods
Although it does not say so specifically in each description, all methods are applied by aeid.
More information about the level 4 multiple-concentration processing is available in the package vignette, "Data_processing."
- bmad.aeid.lowconc.twells
Calculate the baseline median absolute value (bmad) as the median absolute deviation of normalized response values (rep) for test compound wells (wllt = t) with concentration index (cndx) equal to 1 or 2.
- bmad.aeid.lowconc.nwells
Calculate the baseline median absolute value (bmad) as the median absolute deviation of normalized response values (resp) for neutral control wells (wllt = n).
- onesd.aeid.lowconc.twells
Calculate one standard deviation of the normalized response for test compound wells (wllt = t) with a concentration index (cndx) of 1 or 2;
onesd=\sqrt{\sum{(resp-mean(resp))^{2}}/(n-1)}
. Used to establish BMR and therefore required for tcplfit2 processing.- bidirectional.false
Limits bidirectional fitting and processes data in positive analysis direction only. Use for gain-of-signal or inverted data.
- bmad5.onesd16.static
Replace baseline median absolute deviation (bmad) with 5 and one standard deviation (osd) of the normalized response for test compound wells (wllt = t) with a concentration index (cndx) of 1 or 2 with 16. Typically used for binary data where values would otherwise be 0; non-zero values are required for tcplfit2 processing.
Note
This function is not exported and is not intended to be used by the user.
See Also
mc4
, Method functions
to query what
methods get applied to each aeid