adjust_trajectories {rbmi}

Adjust trajectories due to the intercurrent event (ICE)

Description

Adjust trajectories due to the intercurrent event (ICE)

Usage

adjust_trajectories(
  distr_pars_group,
  outcome,
  ids,
  ind_ice,
  strategy_fun,
  distr_pars_ref = NULL
)

Arguments

distr_pars_group

Named list containing the simulation parameters of the multivariate normal distribution assumed for the given treatment group. It contains the following elements:

• mu: Numeric vector indicating the mean outcome trajectory. It should include the outcome at baseline.

• sigma Covariance matrix of the outcome trajectory.

outcome

Numeric variable that specifies the longitudinal outcome.

ids

Factor variable that specifies the id of each subject.

ind_ice

A binary variable that takes value 1 if the corresponding outcome is affected by the ICE and 0 otherwise.

strategy_fun

Function implementing trajectories after the intercurrent event (ICE). Must be one of getStrategies(). See getStrategies() for details.

distr_pars_ref

Optional. Named list containing the simulation parameters of the reference arm. It contains the following elements:

• mu: Numeric vector indicating the mean outcome trajectory assuming no ICEs. It should include the outcome at baseline.

• sigma Covariance matrix of the outcome trajectory assuming no ICEs.

Value

A numeric vector containing the adjusted trajectories.

See Also

adjust_trajectories_single().