calc_allrmds {psm3mkv}

Calculate restricted mean durations for each health state and all three models

Description

Calculate restricted mean durations for each health state (progression free and progressed disease) for all three models (partitioned survival, clock forward state transition model, clock reset state transition model).

Usage

calc_allrmds(
  ptdata,
  inclset = 0,
  dpam,
  psmtype = "simple",
  cuttime = 0,
  Ty = 10,
  lifetable = NA,
  discrate = 0,
  rmdmethod = "int",
  timestep = 1,
  boot = FALSE
)

Arguments

ptdata

Dataset of patient level data. Must be a tibble with columns named:

• ptid: patient identifier

• pfs.durn: duration of PFS from baseline

• pfs.flag: event flag for PFS (=1 if progression or death occurred, 0 for censoring)

• os.durn: duration of OS from baseline

• os.flag: event flag for OS (=1 if death occurred, 0 for censoring)

• ttp.durn: duration of TTP from baseline (usually should be equal to pfs.durn)

• ttp.flag: event flag for TTP (=1 if progression occurred, 0 for censoring).

inclset

Vector to indicate which patients to include in analysis

dpam

List of statistical fits to each endpoint required in PSM, STM-CF and STM-CR models.

psmtype

Either "simple" or "complex" PSM formulation

cuttime

Time cutoff - this is nonzero for two-piece models.

Ty

Time duration over which to calculate. Assumes input is in years, and patient-level data is recorded in weeks.

lifetable

Optional, a life table. Columns must include lttime (time in years, or 52.18 times shorter than the time index elsewhere, starting from zero) and lx

discrate

Discount rate (% per year)

rmdmethod

can be "int" (default for full integral calculations) or "disc" for approximate discretized calculations

timestep

required if method=="int", default being 1

boot

logical flag to indicate whether abbreviated output is required (default = FALSE), for example for bootstrapping

Value

List of detailed numeric results

• cutadj indicates the survival function and area under the curves for PFS and OS up to the cutpoint

• results provides results of the restricted means calculations, by model and state.

Examples

# Create dataset and fit survival models (splines)
bosonc <- create_dummydata("flexbosms")
fits <- fit_ends_mods_par(bosonc)
# Pick out best distribution according to min AIC
params <- list(
  ppd = find_bestfit(fits$ppd, "aic")$fit,
  ttp = find_bestfit(fits$ttp, "aic")$fit,
  pfs = find_bestfit(fits$pfs, "aic")$fit,
  os = find_bestfit(fits$os, "aic")$fit,
  pps_cf = find_bestfit(fits$pps_cf, "aic")$fit,
  pps_cr = find_bestfit(fits$pps_cr, "aic")$fit
)
# RMD using default "int" method, no lifetable constraint
calc_allrmds(bosonc, dpam=params)
# RMD using discretized ("disc") method, no lifetable constraint
calc_allrmds(bosonc, dpam=params, rmdmethod="disc", timestep=1, boot=TRUE)