run_covsearch {pharmr} | R Documentation |
run_covsearch
Description
Run COVsearch tool. For more details, see :ref:covsearch
.
Usage
run_covsearch(
search_space,
p_forward = 0.01,
p_backward = 0.001,
max_steps = -1,
algorithm = "scm-forward-then-backward",
results = NULL,
model = NULL,
max_eval = FALSE,
adaptive_scope_reduction = FALSE,
strictness = "minimization_successful or (rounding_errors and sigdigs>=0.1)",
naming_index_offset = 0,
...
)
Arguments
search_space |
(str or ModelFeatures) MFL of covariate effects to try |
p_forward |
(numeric) The p-value to use in the likelihood ratio test for forward steps |
p_backward |
(numeric) The p-value to use in the likelihood ratio test for backward steps |
max_steps |
(numeric) The maximum number of search steps to make |
algorithm |
(str) The search algorithm to use. Currently, 'scm-forward' and 'scm-forward-then-backward' are supported. |
results |
(ModelfitResults (optional)) Results of model |
model |
(Model (optional)) Pharmpy model |
max_eval |
(logical) Limit the number of function evaluations to 3.1 times that of the base model. Default is FALSE. |
adaptive_scope_reduction |
(logical) Stash all non-significant parameter-covariate effects to be tested after all significant effects have been tested. Once all these have been tested, try adding the stashed effects once more with a regular forward approach. Default is FALSE |
strictness |
(str (optional)) Strictness criteria |
naming_index_offset |
(numeric (optional)) index offset for naming of runs. Default is 0 |
... |
Arguments to pass to tool |
Value
(COVSearchResults) COVsearch tool result object
Examples
## Not run:
model <- load_example_model("pheno")
results <- load_example_modelfit_results("pheno")
search_space <- 'COVARIATE(c(CL, V), c(AGE, WT), EXP)'
res <- run_covsearch(search_space, model=model, results=results)
## End(Not run)