npde-package {npde}

Normalised prediction distribution errors for nonlinear mixed-effect models

Description

Routines to compute normalised prediction distribution errors, a metric designed to evaluate non-linear mixed effect models such as those used in pharmacokinetics and pharmacodynamics

Author(s)

Emmanuelle Comets, Karl Brendel, Thi Huyen Tram Nguyen, France Mentre

Maintainer: Emmanuelle Comets <[e-mail]>

References

K. Brendel, E. Comets, C. Laffont, C. Laveille, and F. Mentre. Metrics for external model evaluation with an application to the population pharmacokinetics of gliclazide. Pharmaceutical Research, 23:2036–49, 2006.

PDF documentation for npde 3.0: https://github.com/ecomets/npde30/blob/main/userguide_npde_3.0.pdf

Examples

data(theopp)
data(simtheopp)

# Calling autonpde with dataframes

x<-autonpde(theopp,simtheopp,ix="Time",iy="Conc",iid="ID",boolsave=FALSE)
print(x)