calc_posterior {monitOS}

Function which calculates for k=1, ..., K, Pr(log-HR >= lhr_null | theta.hat.k = lhr_con.k) i.e. the posterior probability the true OS log-hr exceeds the minimum unacceptable OS log-HR given the estimate of the log-hr at analysis k equals lhr_con.k (i.e. the estimate is equal to the stage k 'continuation threshold').

Description

Function which calculates for k=1, ..., K, Pr(log-HR >= lhr_null | theta.hat.k = lhr_con.k) i.e. the posterior probability the true OS log-hr exceeds the minimum unacceptable OS log-HR given the estimate of the log-hr at analysis k equals lhr_con.k (i.e. the estimate is equal to the stage k 'continuation threshold').

Usage

calc_posterior(lhr_con, lhr_null, events)

Arguments

lhr_con

vector of length K (# number of looks at OS data) containing 'continuation' thresholds on log-HR scale

lhr_null

scalar - minumum unacceptable OS log-HR

events

vector length K - number of OS events at each look at the data

Value

vector of length K - continuation thresholds expressed on posterior probability scale