Mediation Analysis with External Summary-Level Information on Total Effect


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Documentation for package ‘messi’ version 0.1.1

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constrained.unpenalized Estimate hard constraint model parameters using cyclical coordinate descent.
Med Simulated data with real mediation effect
messi Implementation of Mediation with External Summary Statistics Information (MESSI) from Boss et al. (2023).
nullMed Simulated data with null mediation effect
plot_messi Forestplot to Summarize Estimation and Inference on alpha_a and beta_m.
rand.eff.coord.desc.unpenalized Cyclical coordinate descent algorithm for the M-step in the EM Algorithm for the maximizing the soft constraint model likelihood.
rand.eff.unpenalized Estimate soft constraint model parameters using the EM algorithm.
unconstrained.unpenalized Estimate unconstrained model parameters.