tissue_masses_flows {httk}

Given a data.table describing a virtual population by the NHANES quantities, generates HTTK physiological parameters for each individual.

Description

Given a data.table describing a virtual population by the NHANES quantities, generates HTTK physiological parameters for each individual.

Usage

tissue_masses_flows(tmf_dt)

Arguments

tmf_dt

A data.table generated by gen_age_height_weight(), containing variables gender, reth, age_months, age_years, weight, and height.

Value

The same data.table, with aditional variables describing tissue masses and flows.

Author(s)

Caroline Ring

References

Barter, Zoe E., et al. "Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human micro-somal protein and hepatocellularity per gram of liver." Current Drug Metabolism 8.1 (2007): 33-45.

Birnbaum, L., et al. "Physiological parameter values for PBPK models." International Life Sciences Institute, Risk Science Institute, Washington, DC (1994).

Geigy Pharmaceuticals, "Scientific Tables", 7th Edition, John Wiley and Sons (1970)

McNally, Kevin, et al. "PopGen: a virtual human population generator." Toxicology 315 (2014): 70-85.

Ring CL, Pearce RG, Setzer RW, Wetmore BA, Wambaugh JF (2017). “Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability.” Environment International, 106, 105–118.