| pregnonpregaucs {httk} | R Documentation |
AUCs for Pregnant and Non-Pregnant Women
Description
Dallmann et al. (2018) includes compiled literature descriptions of toxicokinetic summary statistics, including time-integrated plasma concentrations (area under the curve or AUC) for drugs administered to a sample of subjects including both pregnant and non-pregnant women. The circumstances of the dosing varied slightly between drugs and are summarized in the table.
Usage
pregnonpregaucs
Format
data.frame
Source
Kapraun DF, Sfeir M, Pearce RG, Davidson-Fritz SE, Lumen A, Dallmann A, Judson RS, Wambaugh JF (2022). “Evaluation of a rapid, generic human gestational dose model.” Reproductive Toxicology, 113, 172–188.
References
Dallmann A, Ince I, Coboeken K, Eissing T, Hempel G (2018). “A physiologically based pharmacokinetic model for pregnant women to predict the pharmacokinetics of drugs metabolized via several enzymatic pathways.” Clinical pharmacokinetics, 57(6), 749–768.