mcnally_dt {httk} | R Documentation |
Reference tissue masses and flows from tables in McNally et al. 2014.
Description
Reference tissue masses, flows, and residual variance distributions from Tables 1, 4, and 5 of McNally et al. 2014.
Usage
mcnally_dt
Format
A data.table with variables:
tissue
Body tissue
gender
Gender: Male or Female
mass_ref
Reference mass in kg, from Reference Man
mass_cv
Coefficient of variation for mass
mass_dist
Distribution for mass: Normal or Log-normal
flow_ref
Reference flow in L/h, from Reference Man
flow_cv
Coefficient of variation for flow (all normally distributed)
height_ref
Reference heights (by gender)
CO_ref
Reference cardiac output by gender
flow_frac
Fraction of CO flowing to each tissue:
flow_ref
/CO_ref
Author(s)
Caroline Ring
Source
McNally K, Cotton R, Hogg A, Loizou G. "PopGen: A virtual human population generator." Toxicology 315, 70-85, 2004.
References
Ring CL, Pearce RG, Setzer RW, Wetmore BA, Wambaugh JF (2017). “Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability.” Environment International, 106, 105–118.