get_lit_css {httk}

Get literature Css

Description

This function retrieves a steady-state plasma concentration as a result of infusion dosing from the Wetmore et al. (2012) and (2013) publications and other literature.

Usage

get_lit_css(
  chem.cas = NULL,
  chem.name = NULL,
  daily.dose = 1,
  which.quantile = 0.95,
  species = "Human",
  clearance.assay.conc = NULL,
  output.units = "mg/L",
  suppress.messages = FALSE
)

Arguments

chem.cas

Either the cas number or the chemical name must be specified.

chem.name

Either the chemical name or the CAS number must be specified.

daily.dose

Total daily dose infused in units of mg/kg BW/day. Defaults to 1 mg/kg/day.

which.quantile

Which quantile from the SimCYP Monte Carlo simulation is requested. Can be a vector.

species

Species desired (either "Rat" or default "Human").

clearance.assay.conc

Concentration of chemical used in measureing intrinsic clearance data, 1 or 10 uM.

output.units

Returned units for function, defaults to mg/L but can also be uM (specify units = "uM").

suppress.messages

Whether or not the output message is suppressed.

Value

A numeric vector with the literature steady-state plasma concentration (1 mg/kg/day) for the requested quantiles

Author(s)

John Wambaugh

References

Wetmore, B.A., Wambaugh, J.F., Ferguson, S.S., Sochaski, M.A., Rotroff, D.M., Freeman, K., Clewell, H.J., Dix, D.H., Andersen, M.E., Houck, K.A., Allen, B., Judson, R.S., Sing, R., Kavlock, R.J., Richard, A.M., and Thomas, R.S., "Integration of Dosimetry, Exposure and High-Throughput Screening Data in Chemical Toxicity Assessment," Toxicological Sciences 125 157-174 (2012)

Wetmore, B.A., Wambaugh, J.F., Ferguson, S.S., Li, L., Clewell, H.J. III, Judson, R.S., Freeman, K., Bao, W, Sochaski, M.A., Chu T.-M., Black, M.B., Healy, E, Allen, B., Andersen M.E., Wolfinger, R.D., and Thomas R.S., "The Relative Impact of Incorporating Pharmacokinetics on Predicting in vivo Hazard and Mode-of-Action from High-Throughput in vitro Toxicity Assays" Toxicological Sciences, 132:327-346 (2013).

Wetmore, B. A., Wambaugh, J. F., Allen, B., Ferguson, S. S., Sochaski, M. A., Setzer, R. W., Houck, K. A., Strope, C. L., Cantwell, K., Judson, R. S., LeCluyse, E., Clewell, H.J. III, Thomas, R.S., and Andersen, M. E. (2015). "Incorporating High-Throughput Exposure Predictions with Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing" Toxicological Sciences, kfv171.

Examples

get_lit_css(chem.cas="34256-82-1")

get_lit_css(chem.cas="34256-82-1",species="Rat",which.quantile=0.5)

get_lit_css(chem.cas="80-05-7", daily.dose = 1,which.quantile = 0.5, output.units = "uM")