| fetalpcs {httk} | R Documentation |
Fetal Partition Coefficients
Description
Partition coefficients were measured for tissues, including placenta, in vitro by Csanady et al. (2002) for Bisphenol A and Diadzen. Curley et al. (1969) measured the concentration of a variety of pesticides in the cord blood of newborns and in the tissues of infants that were stillborn.
Usage
fetalpcs
Format
data.frame
Details
Three of the chemicals studied by Curley et al. (1969) were modeled by Weijs et al. (2013) using the same partition coefficients for mother and fetus. The values used represented "prior knowledge" summarizing the available literature.
Source
Kapraun DF, Sfeir M, Pearce RG, Davidson-Fritz SE, Lumen A, Dallmann A, Judson RS, Wambaugh JF (2022). “Evaluation of a rapid, generic human gestational dose model.” Reproductive Toxicology, 113, 172–188.
References
Csanady G, Oberste-Frielinghaus H, Semder B, Baur C, Schneider K, Filser J (2002). “Distribution and unspecific protein binding of the xenoestrogens bisphenol A and daidzein.” Archives of toxicology, 76(5-6), 299–305. Curley A, Copeland MF, Kimbrough RD (1969). “Chlorinated hydrocarbon insecticides in organs of stillborn and blood of newborn babies.” Archives of Environmental Health: An International Journal, 19(5), 628–632. Weijs L, Yang RS, Das K, Covaci A, Blust R (2013). “Application of Bayesian population physiologically based pharmacokinetic (PBPK) modeling and Markov chain Monte Carlo simulations to pesticide kinetics studies in protected marine mammals: DDT, DDE, and DDD in harbor porpoises.” Environmental science & technology, 47(9), 4365–4374.