calc_total_clearance {httk}

Calculate the total plasma clearance.

Description

This function calculates the total clearance rate for a one compartment model for plasma where clearance is entirely due to metablism by the liver and glomerular filtration in the kidneys, identical to clearance of three compartment steady state model.

Usage

calc_total_clearance(
  chem.cas = NULL,
  chem.name = NULL,
  dtxsid = NULL,
  parameters = NULL,
  species = "Human",
  suppress.messages = FALSE,
  default.to.human = FALSE,
  well.stirred.correction = TRUE,
  restrictive.clearance = TRUE,
  adjusted.Funbound.plasma = TRUE,
  ...
)

Arguments

chem.cas

Either the chemical name, CAS number, or the parameters must be specified.

chem.name

Either the chemical name, CAS number, or the parameters must be specified.

dtxsid

EPA's 'DSSTox Structure ID (https://comptox.epa.gov/dashboard) the chemical must be identified by either CAS, name, or DTXSIDs

parameters

Chemical parameters from parameterize_steadystate function, overrides chem.name and chem.cas.

species

Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").

suppress.messages

Whether or not the output message is suppressed.

default.to.human

Substitutes missing animal values with human values if true.

well.stirred.correction

Uses correction in calculation of hepatic clearance for well-stirred model if TRUE. This assumes clearance relative to amount unbound in whole blood instead of plasma, but converted to use with plasma concentration.

restrictive.clearance

Protein binding is not taken into account (set to 1) in liver clearance if FALSE.

adjusted.Funbound.plasma

Uses adjusted Funbound.plasma when set to TRUE.

...

Additional parameters passed to parameterize_steadystate if parameters is NULL.

Value

Total Clearance

Units of L/h/kg BW.

Author(s)

John Wambaugh

Examples

calc_total_clearance(chem.name="Ibuprofen")