calc_hepatic_clearance {httk} | R Documentation |
Calculate the hepatic clearance (deprecated).
Description
This function is included for backward compatibility. It calls
calc_hep_clearance
which
calculates the hepatic clearance in plasma for a well-stirred model
or other type if specified. Based on Ito and Houston (2004)
Usage
calc_hepatic_clearance(
chem.name = NULL,
chem.cas = NULL,
dtxsid = NULL,
parameters = NULL,
species = "Human",
default.to.human = FALSE,
hepatic.model = "well-stirred",
suppress.messages = FALSE,
well.stirred.correction = TRUE,
restrictive.clearance = TRUE,
adjusted.Funbound.plasma = TRUE,
...
)
Arguments
chem.name |
Either the chemical name, CAS number, or the parameters must be specified. |
chem.cas |
Either the chemical name, CAS number, or the parameters must be specified. |
dtxsid |
EPA's DSSTox Structure ID (https://comptox.epa.gov/dashboard) the chemical must be identified by either CAS, name, or DTXSIDs |
parameters |
Chemical parameters from parameterize_steadystate function, overrides chem.name and chem.cas. |
species |
Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human"). |
default.to.human |
Substitutes missing animal values with human values if true. |
hepatic.model |
Model used in calculating hepatic clearance, unscaled, parallel tube, dispersion, or default well-stirred. |
suppress.messages |
Whether or not to suppress the output message. |
well.stirred.correction |
Uses correction in calculation of hepatic clearance for well-stirred model if TRUE for hepatic.model well-stirred. This assumes clearance relative to amount unbound in whole blood instead of plasma, but converted to use with plasma concentration. |
restrictive.clearance |
Protein binding not taken into account (set to 1) in liver clearance if FALSE. |
adjusted.Funbound.plasma |
Whether or not to use Funbound.plasma adjustment if calculating Rblood2plasma. |
... |
Additional parameters passed to parameterize_steadystate if parameters is NULL. |
Value
Hepatic Clearance |
Units of L/h/kg BW. |
Author(s)
John Wambaugh and Robert Pearce
References
Ito, K., & Houston, J. B. (2004). "Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes." Pharmaceutical Tesearch, 21(5), 785-792.
Examples
calc_hep_clearance(chem.name="Ibuprofen",hepatic.model='unscaled')
calc_hep_clearance(chem.name="Ibuprofen",well.stirred.correction=FALSE)