calc_hepatic_clearance {httk}

Calculate the hepatic clearance (deprecated).

Description

This function is included for backward compatibility. It calls calc_hep_clearance which calculates the hepatic clearance in plasma for a well-stirred model or other type if specified. Based on Ito and Houston (2004)

Usage

calc_hepatic_clearance(
  chem.name = NULL,
  chem.cas = NULL,
  dtxsid = NULL,
  parameters = NULL,
  species = "Human",
  default.to.human = FALSE,
  hepatic.model = "well-stirred",
  suppress.messages = FALSE,
  well.stirred.correction = TRUE,
  restrictive.clearance = TRUE,
  adjusted.Funbound.plasma = TRUE,
  ...
)

Arguments

chem.name

Either the chemical name, CAS number, or the parameters must be specified.

chem.cas

Either the chemical name, CAS number, or the parameters must be specified.

dtxsid

EPA's DSSTox Structure ID (https://comptox.epa.gov/dashboard) the chemical must be identified by either CAS, name, or DTXSIDs

parameters

Chemical parameters from parameterize_steadystate function, overrides chem.name and chem.cas.

species

Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").

default.to.human

Substitutes missing animal values with human values if true.

hepatic.model

Model used in calculating hepatic clearance, unscaled, parallel tube, dispersion, or default well-stirred.

suppress.messages

Whether or not to suppress the output message.

well.stirred.correction

Uses correction in calculation of hepatic clearance for well-stirred model if TRUE for hepatic.model well-stirred. This assumes clearance relative to amount unbound in whole blood instead of plasma, but converted to use with plasma concentration.

restrictive.clearance

Protein binding not taken into account (set to 1) in liver clearance if FALSE.

adjusted.Funbound.plasma

Whether or not to use Funbound.plasma adjustment if calculating Rblood2plasma.

...

Additional parameters passed to parameterize_steadystate if parameters is NULL.

Value

Hepatic Clearance

Units of L/h/kg BW.

Author(s)

John Wambaugh and Robert Pearce

References

Ito, K., & Houston, J. B. (2004). "Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes." Pharmaceutical Tesearch, 21(5), 785-792.

Examples

calc_hep_clearance(chem.name="Ibuprofen",hepatic.model='unscaled')
calc_hep_clearance(chem.name="Ibuprofen",well.stirred.correction=FALSE)