| available_rblood2plasma {httk} | R Documentation |
Find the best available ratio of the blood to plasma concentration constant.
Description
This function finds the best available constant ratio of the blood
concentration to the plasma concentration, using
get_rblood2plasma and calc_rblood2plasma.
Usage
available_rblood2plasma(
chem.cas = NULL,
chem.name = NULL,
dtxsid = NULL,
species = "Human",
adjusted.Funbound.plasma = TRUE,
suppress.messages = FALSE
)
Arguments
chem.cas |
Either the CAS number or the chemical name must be specified. |
chem.name |
Either the chemical name or the CAS number must be specified. |
dtxsid |
EPA's 'DSSTox Structure ID (https://comptox.epa.gov/dashboard) the chemical must be identified by either CAS, name, or DTXSIDs |
species |
Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human"). |
adjusted.Funbound.plasma |
Whether or not to use Funbound.plasma adjustment if calculating Rblood2plasma. |
suppress.messages |
Whether or not to display relevant warning messages to user. |
Details
Either retrieves a measured blood:plasma concentration ratio from the
chem.physical_and_invitro.data table or calculates it using the red blood cell
partition coefficient predicted with Schmitt's method
If available, in vivo data (from chem.physical_and_invitro.data)
for the
given species is returned, substituting the human in vivo value when missing
for other species. In the absence of in vivo data, the value is calculated
with calc_rblood2plasma for the given species. If Funbound.plasma is
unvailable for the given species, the human Funbound.plasma is substituted.
If none of these are available, the mean human Rblood2plasma from
chem.physical_and_invitro.data is returned.
details than the description above ~~
Value
The blood to plasma chemical concentration ratio – measured if available, calculated if not.
Author(s)
Robert Pearce
See Also
Examples
available_rblood2plasma(chem.name="Bisphenol A",adjusted.Funbound.plasma=FALSE)
available_rblood2plasma(chem.name="Bisphenol A",species="Rat")