hctrial {hctrial}

hctrial: A package for designing phase 2 clinical trials adjusting for heterogeneous populations.

Description

The hctrial package provides functions for designing phase 2 clinical trials that adjust for the heterogeneity in the population.

Details

Two different ways are considered for designing a trial: based on known subgroups or based on historical data.

For initializing a stratified trial, use strat_start.

At interim, strat_interim should be used to adjust the trial.

At the end of the study, strat_end is used to adjust the trial again.

hist_start, hist_interim and hist_end work analogously, but are based on historical controls.