hwe.hardy {gap}

Hardy-Weinberg equilibrium test using MCMC

Description

Hardy-Weinberg equilibrium test using MCMC

Usage

hwe.hardy(a, alleles = 3, seed = 3000, sample = c(1000, 1000, 5000))

Arguments

a

an array containing the genotype counts, as integer.

alleles

number of allele at the locus, greater than or equal to 3, as integer.

seed

pseudo-random number seed, as integer.

sample

optional, parameters for MCMC containing number of chunks, size of a chunk and burn-in steps, as integer.

Details

Hardy-Weinberg equilibrium test by MCMC

Value

The returned value is a list containing:

• method Hardy-Weinberg equilibrium test using MCMC.

• data.name name of used data if x is given.

• p.value Monte Carlo p value.

• p.value.se standard error of Monte Carlo p value.

• switches percentage of switches (partial, full and altogether).

Note

Codes are commented for taking x a genotype object, as genotype to prepare a and alleles on the fly.

Adapted from HARDY, testable with -Dexecutable as standalone program.

keywords htest

Author(s)

Sun-Wei Guo, Jing Hua Zhao, Gregor Gorjanc

Source

https://sites.stat.washington.edu/thompson/Genepi/pangaea.shtml

References

Guo SW, Thompson EA (1992). “Performing the exact test of Hardy-Weinberg proportion for multiple alleles.” Biometrics, 48(2), 361-72. ISSN 0006-341X (Print) 0006-341x.

See Also

hwe, genetics::HWE.test, genetics::genotype

Examples

## Not run: 
 # example 2 from hwe.doc:
   a<-c(
   3,
   4, 2,
   2, 2, 2,
   3, 3, 2, 1,
   0, 1, 0, 0, 0,
   0, 0, 0, 0, 0, 1,
   0, 0, 1, 0, 0, 0, 0,
   0, 0, 0, 2, 1, 0, 0, 0)
   ex2 <- hwe.hardy(a=a,alleles=8)

   # example using HLA
   data(hla)
   x <- hla[,3:4]
   y <- pgc(x,handle.miss=0,with.id=1)
   n.alleles <- max(x,na.rm=TRUE)
   z <- vector("numeric",n.alleles*(n.alleles+1)/2)
   z[y$idsave] <- y$wt
   hwe.hardy(a=z,alleles=n.alleles)

   # with use of class 'genotype'
   # this is to be fixed
   library(genetics)
   hlagen <- genotype(a1=x$DQR.a1, a2=x$DQR.a2,
                      alleles=sort(unique(c(x$DQR.a1, x$DQR.a2))))
   hwe.hardy(hlagen)

   # comparison with hwe
   hwe(z,data.type="count")

   # to create input file for HARDY
   print.tri<-function (xx,n) {
       cat(n,"\n")
       for(i in 1:n) {
           for(j in 1:i) {
               cat(xx[i,j]," ")
           }
       cat("\n")
       }
       cat("100 170 1000\n")
   }
   xx<-matrix(0,n.alleles,n.alleles)
   xxx<-lower.tri(xx,diag=TRUE)
   xx[xxx]<-z
   sink("z.dat")
   print.tri(xx,n.alleles)
   sink()
   # now call as: hwe z.dat z.out

## End(Not run)